COGNITIVE · Injectable
VIP.
Neuroprotective and anti-inflammatory peptide
How it works
Class & mechanism.
Class
Endogenous Neuropeptide (Pleiotropic Immunomodulator)
Mechanism
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide originally isolated from gut tissue but produced throughout the CNS, immune system, and peripheral tissues. It signals through two G-protein-coupled receptors — VPAC1 and VPAC2 — activating adenylate cyclase and raising intracellular cAMP, which drives broad anti-inflammatory, vasodilatory, and neuroprotective effects. In the brain's suprachiasmatic nucleus (SCN), VIP is produced by a specialised pacemaker neuronal population and functions as the master synchronisation signal that coordinates ~10,000 individual circadian clock neurons into a coherent daily rhythm. Without functional VIP signalling, individual SCN neurons lose synchrony and generate fragmented, desynchronised circadian activity.
Did you know
VIP is the reason your body knows what time it is. Without it, the 10,000 individual 'clock' neurons in your brain each start running on their own time — like an orchestra with no conductor — and your biological rhythms fragment into chaos. One peptide is the entire synchronisation signal for your internal clock.
Benefits
What it does.
Synchronises the master biological clock (SCN) — essential for coherent circadian rhythm and sleep-wake regulation
Potent anti-inflammatory: reduces pro-inflammatory cytokines (TNF-α, IL-6, IL-12) and shifts immune response toward tolerance
Vasodilatory and cardioprotective: improves vascular function and reduces pulmonary arterial resistance
Neuroprotective and neurotrophic: supports neuronal survival and reduces neuroinflammation in CNS disease models
The science
Peer-reviewed findings.
Research supporting this compound's mechanisms and safety profile.
VIP-knockout mice on a light-dark schedule appear normal, but when lights are removed they reveal complete internal circadian desynchrony — their SCN neurons generate multiple fragmented rhythms. Daily VIP administration fully restores neuronal synchrony in arrhythmic SCN cells.
SOURCE · Herzog & Aton, Washington University / ScienceDaily (2005); Aton et al., Nature Neuroscience
Exogenous VIP administration in murine models of autoimmune disease (rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis) significantly reduced disease severity by shifting the Th1/Th17 inflammatory balance toward Th2/Treg tolerance, via VPAC1/VPAC2 receptor-cAMP signalling.
SOURCE · Abad et al., MDPI International Journal of Molecular Sciences 21(1):65 (2020)
VIP is synthesised by both neurons and immune cells during autoimmune responses, acting as an endogenous brake on excessive inflammation — making exogenous VIP a therapeutic candidate for restoring immune homeostasis in chronic inflammatory conditions.
SOURCE · Gonzalez-Rey & Delgado, Trends in Molecular Medicine (2007)
Protocol
How to use it.
Dosing
Typically 50–100 mcg via slow IV infusion or subcutaneous injection; inhalation routes used in pulmonary hypertension research. IV administration: infuse slowly to minimise transient blood pressure effects. Dosing frequency depends on clinical indication — some protocols use daily dosing, others 3x/week.
Cycle
Protocols vary by indication. Anti-inflammatory and circadian reset applications typically use 4–8 week courses. Longer-term use requires medical supervision given cardiovascular monitoring needs.
Contraindications
When to skip it.
Caution with low blood pressure or cardiovascular instability — VIP causes transient vasodilation and can temporarily reduce blood pressure. Rapid IV infusion may cause flushing, headache, or dizziness. Avoid in known peptide hypersensitivity. Contraindicated in uncontrolled hypotension.
Always cleared with your concierge before protocol start.
Pricing
What it costs.
Indicative range for VIP, sourced from vetted US and EU dispensing suppliers. Concierge confirms the exact figure once your match is locked.
Indicative range (USD)
Sourced through vetted dispensing partners in the United States and European Union. Concierge confirms the exact figure once your match is locked.
- 0199% purity verified, third-party tested
- 02Includes vial and reconstitution guidance
- 03Concierge supplier match included with every protocol
See VIP pricing — and your supplier match.
Pricing is unlocked once we know who you are. Take the 3-minute quiz and we'll match you to a US or EU dispensary based on your location and protocol fit.
- Live USD price range
- US & EU supplier shortlist
- Concierge sign-off on dosing
Indicative price range: $120–$180 USD