IMMUNE · Injectable
Thymogen.
Thymus-derived immune restoration peptide
How it works
Class & mechanism.
Class
Thymic Dipeptide Bioregulator
Mechanism
Thymogen (L-Glu-L-Trp; EW dipeptide) is a synthetic dipeptide bioregulator originally isolated from the calf thymus-derived polypeptide complex Thymalin. It mimics natural thymic signaling by binding to the AACG DNA sequence motif and interacting with histone proteins, altering chromatin conformation and gene accessibility in immune cells. Functionally, Thymogen modulates the cAMP/cGMP ratio by influencing phosphodiesterase activity — downregulating excess cyclic nucleotide catabolism — which normalizes intracellular signaling thresholds in T-lymphocytes. This drives differentiation of T-lymphocyte precursors into mature immunocompetent T-cells (evidenced by SC-1 antigen → Thy-1 antigen transition), enhances NK cell activity, stimulates interferon secretion, and activates neutrophil chemotaxis and phagocytosis without triggering autoimmune overstimulation.
Did you know
Thymogen is just two amino acids long — making it one of the simplest therapeutic peptides in existence — yet it interacts directly with DNA to regulate dozens of genes involved in aging, immunity, and cancer suppression, demonstrating that molecular size has nothing to do with biological power.
Benefits
What it does.
Restores T-cell maturation and immune competence in secondary immunodeficiency states — positive outcomes in 94.4% of research models
Activates natural killer cell activity and enhances interferon secretion for improved viral and cancer surveillance
Nasal spray formulation increases secretory IgA (sIgA) levels at respiratory mucosa — clinically validated for prevention and treatment of upper respiratory tract infections
Demonstrated anti-carcinogenic effect in rat studies: 12 months of Thymogen reduced total tumor incidence 1.5×, malignant tumors 1.7×, and hematopoietic malignancies 3.4× compared to controls
Geroprotective properties: extended maximum lifespan in treated rats by 10.4% and slowed biological aging rate (Gompertz alpha coefficient reduced from 0.0071 to 0.0041/day)
The science
Peer-reviewed findings.
Research supporting this compound's mechanisms and safety profile.
In a 12-month controlled rat study (n=76), subcutaneous Thymogen (5 mcg/rat, 5×/week) reduced total tumor incidence 1.5-fold, malignant tumor incidence 1.7-fold, and hematopoietic malignancies 3.4-fold vs. controls; maximum lifespan of top 10% survivors extended by ~100 days (949 vs. 1048 days)
SOURCE · Anisimov & Khavinson, PubMed PMID: 11707921 — 'Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats'
Military study (Russian ARVI trial) demonstrated clinico-epidemiological efficacy of Thymogen nasal spray for prevention and treatment of acute respiratory viral infections; intranasal delivery confirmed to elevate respiratory mucosal sIgA and reduce infection incidence
SOURCE · Cited in PeptideInsight clinical review; Khavinson laboratory military clinical data (1990–2000s)
PMC review of thymalin and Thymogen molecular mechanisms confirmed: the EW dipeptide regulates heat-shock protein synthesis, cytokine production, fibrinolysis, gerontogene expression, and cell differentiation/proliferation/apoptosis — with over 25 million patients treated since 1990 registration with no reported allergic or serious side reactions
SOURCE · PMC8365293 — 'The Use of Thymalin for Immunocorrection and Molecular Aspects of Biological Activity' (2021)
Protocol
How to use it.
Dosing
Injectable (IM): 100–1,000 mcg (1–10 mL of 100 mcg/mL solution) daily for 3–10 days for severe immunodeficiency or acute infection recovery. Nasal spray: 25 mcg per nostril, twice daily (adults). Research protocols: 5–10 mcg/day for immune enhancement studies. Oral and topical formulations exist in Eastern European markets.
Cycle
Acute infection/immunodeficiency: 3–10 day intensive course. Maintenance and anti-aging protocols: 10–14 day cycles, 2–4 times per year. Nasal spray: continuous seasonal use permitted. Clinical use in Russia ongoing since 1990 without significant long-term safety signals.
Contraindications
When to skip it.
Excellent safety record with over 25 million patient treatments and no reported allergic reactions. Mild and rare side effects: local injection site reactions, transient nasal irritation (nasal spray). Being a dipeptide metabolized to natural amino acids (glutamic acid + tryptophan), accumulation risk is minimal. Long-term human data beyond Russian registry are limited. Physician guidance recommended for severe immunodeficiency or cancer contexts.
Always cleared with your concierge before protocol start.
Pricing
What it costs.
Indicative range for Thymogen, sourced from vetted US and EU dispensing suppliers. Concierge confirms the exact figure once your match is locked.
Indicative range (USD)
Sourced through vetted dispensing partners in the United States and European Union. Concierge confirms the exact figure once your match is locked.
- 0199% purity verified, third-party tested
- 02Includes vial and reconstitution guidance
- 03Concierge supplier match included with every protocol
See Thymogen pricing — and your supplier match.
Pricing is unlocked once we know who you are. Take the 3-minute quiz and we'll match you to a US or EU dispensary based on your location and protocol fit.
- Live USD price range
- US & EU supplier shortlist
- Concierge sign-off on dosing
Indicative price range: $119–$179 USD