PERFORMANCE · Injectable
Ipamorelin / CJC-1295 Blend.
Gold standard GH combination
How it works
Class & mechanism.
Class
GHRH Analogue + GHRP Combination
Mechanism
The Ipamorelin/CJC-1295 No DAC blend co-activates two distinct and complementary receptor systems on pituitary somatotroph cells simultaneously. CJC-1295 No DAC binds GHRH receptors (GHRHR), activating adenylate cyclase and driving cAMP-mediated GH synthesis — amplifying the magnitude of each GH pulse. Ipamorelin simultaneously binds GHS-R1a (ghrelin receptor), suppressing somatostatin tone and triggering rapid GH release via calcium-dependent pathways. Because these pathways converge rather than overlap, the two-receptor co-stimulation produces a synergistic GH output — 3–5× greater than either peptide alone — while preserving pulsatile, physiological release patterns.
Did you know
The combination produces a GH pulse with both an immediate spike AND a sustained elevated baseline — essentially replicating the GH secretion profile of a fit 25-year-old using two injections that cost a fraction of exogenous HGH therapy.
Benefits
What it does.
3–5× greater GH output than either peptide administered alone
Dual-phase kinetics: Ipamorelin provides an immediate GH spike; CJC-1295 sustains elevated GH tone
Superior lean mass preservation and fat loss compared to single-peptide protocols
Improved recovery, sleep architecture, skin quality, and metabolic vitality with a clean hormonal profile (no cortisol elevation)
The science
Peer-reviewed findings.
Research supporting this compound's mechanisms and safety profile.
An early 2000s controlled study of CJC-1295 in mature male models found approximately a 7.5-fold increase in GH pulse amplitude relative to placebo, along with increased total pituitary RNA and GH mRNA — indicating not just acute secretion but potential somatotroph cell proliferation with sustained stimulation.
SOURCE · Biotech Peptides / IRE Journals pharmacological review citing early CJC-1295 clinical cohort data, 2025
A mechanistic review published in IRE Journals (2025) confirmed that combining a GHRH analogue with a GHRP produces 'activation of different but overlapping pathways which are closer to natural GH secretion patterns in the body,' allowing dual baseline stimulation and pulsatile release — minimising receptor downregulation risk associated with single-pathway saturation.
SOURCE · IRE Journals — The Mechanism of Action and Synergy of CJC-1295 And Ipamorelin Peptide Blend (2025)
Protocol
How to use it.
Dosing
Standard blend dosing: 100–200 mcg CJC-1295 No DAC + 100–200 mcg Ipamorelin per injection, administered as a single combined subcutaneous injection once or twice daily. Evening injection before sleep is the primary protocol; some protocols add a pre-workout injection for performance goals. Pre-mixed blends are available from compounding pharmacies at fixed ratios.
Cycle
8–12 week cycles with a 4-week break. The blend's dual-phase action means initial sleep and energy improvements are typically noticeable within the first 2–3 weeks; significant body composition changes (lean mass gain, fat reduction) emerge over 3–6 months of consistent use. IGF-1 levels should be monitored at 6–8 week intervals to guide dose adjustments.
Contraindications
When to skip it.
All contraindications of component peptides apply: active malignancy or high cancer risk (IGF-1 elevation), uncontrolled diabetes, pregnancy or breastfeeding. Side effects are generally mild — transient water retention, flushing, or headache during initial weeks. The selective GHRP profile of Ipamorelin keeps cortisol and prolactin unaffected, reducing the stress-hormone burden common with older stacks. Requires medical supervision.
Always cleared with your concierge before protocol start.
Pricing
What it costs.
Indicative range for Ipamorelin / CJC-1295 Blend, sourced from vetted US and EU dispensing suppliers. Concierge confirms the exact figure once your match is locked.
Indicative range (USD)
Sourced through vetted dispensing partners in the United States and European Union. Concierge confirms the exact figure once your match is locked.
- 0199% purity verified, third-party tested
- 02Includes vial and reconstitution guidance
- 03Concierge supplier match included with every protocol
See Ipamorelin / CJC-1295 Blend pricing — and your supplier match.
Pricing is unlocked once we know who you are. Take the 3-minute quiz and we'll match you to a US or EU dispensary based on your location and protocol fit.
- Live USD price range
- US & EU supplier shortlist
- Concierge sign-off on dosing
Indicative price range: $150–$224 USD