LONGEVITY · Injectable
Epitalon.
Telomere-activating longevity peptide
How it works
Class & mechanism.
Class
Tetrapeptide
Mechanism
Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide derived from Epithalamin, a polypeptide originally isolated from the pineal gland. It directly interacts with promoter regions of the telomerase gene by binding specific ATTTC DNA sequence motifs, inducing expression of hTERT (the catalytic subunit of telomerase), increasing enzymatic activity, and producing measurable telomere elongation — extending cellular replicative lifespan beyond the Hayflick limit. Beyond telomerase activation, Epitalon penetrates cell nuclei to remodel chromatin structure and modulate epigenetic gene expression, while also restoring pineal gland function, boosting melatonin synthesis, and upregulating antioxidant enzymes including superoxide dismutase and glutathione peroxidase.
Did you know
In a 12-year human study, elderly patients who received Epitalon and Thymalin annually for 6 years had 4.1× lower mortality than the control group — the largest mortality reduction ever recorded for a therapeutic peptide in human trials.
Benefits
What it does.
Telomere elongation — induces hTERT expression and activates telomerase to lengthen telomeres in human somatic cells, extending replicative lifespan
Circadian rhythm restoration — a randomized trial in 75 women showed 0.5 mg/day increased melatonin synthesis 1.6-fold and meaningfully reset circadian clock gene expression (Clock, Cry2, Csnk1e)
Neuroprotection and neural plasticity — human fibroblasts reprogrammed to neurons and treated with Epitalon showed increased dendritic length, branching complexity, and synaptic junction counts
Antioxidant defense and DNA repair — enhances superoxide dismutase and glutathione peroxidase activity, reduces oxidative damage, and may restore youthful chromatin structure to support DNA repair
The science
Peer-reviewed findings.
Research supporting this compound's mechanisms and safety profile.
In a 12-year longitudinal clinical trial at two independent Russian and Ukrainian gerontological centers (n=266 elderly patients), Thymalin + Epithalamin treatment reduced all-cause mortality 2.5-fold and cardiovascular mortality by approximately 45%; annual combined treatment over 6 years achieved a 4.1-fold mortality reduction versus controls
SOURCE · Khavinson VK & Morozov VG, Neuroendocrinology Letters, 2003
Epitalon induced a 33% increase in telomere elongation in human somatic cell cultures by upregulating hTERT expression and telomerase enzymatic activity — confirmed in PMC-published research using quantitative telomere length measurement alongside telomerase activity assays
SOURCE · Araj et al., PMC12411320, 2025; Khavinson VK et al., Bull Exp Biol Med, 2003
Randomized controlled trial in 75 women: sublingual Epitalon 0.5 mg/day for 20 days increased urinary 6-sulfatoxymelatonin (melatonin metabolite) 1.6-fold vs placebo, with significant modulation of Clock, Cry2, and Csnk1e circadian gene expression in leukocytes
SOURCE · Randomized clinical study cited in Healthspan/gethealthspan.com review, 2024
Animal studies show Epitalon extends median and maximum lifespan by 12–24% in rodent models and increases superoxide dismutase and glutathione peroxidase activity, supporting its multi-pathway anti-aging action
SOURCE · Khavinson VK et al., Frontiers in Aging, 2026; Anisimov VN et al., Biogerontology, 2003
Protocol
How to use it.
Dosing
5–10 mg/day via subcutaneous injection for 10–20 consecutive days; alternatively, 0.5–1 mg/day sublingually for up to 20 days based on human circadian trials. Injections ideally administered at night due to melatonin-modulating effects.
Cycle
1–2 cycles per year with 4–6 months between cycles; some protocols use 3 cycles per year (1 month on, 3 months off). Long-term effects appear to consolidate during the rest period.
Contraindications
When to skip it.
No severe adverse events reported in multi-year clinical trials. Potential theoretical concern around stimulating telomerase in cancer cells — avoid use in individuals with active malignancy or strong personal/family cancer history. Only the all-L stereoisomeric form has been studied; other forms untested. No large-scale pharmacokinetic data in humans. Not approved outside Russia.
Always cleared with your concierge before protocol start.
Pricing
What it costs.
Indicative range for Epitalon, sourced from vetted US and EU dispensing suppliers. Concierge confirms the exact figure once your match is locked.
Indicative range (USD)
Sourced through vetted dispensing partners in the United States and European Union. Concierge confirms the exact figure once your match is locked.
- 0199% purity verified, third-party tested
- 02Includes vial and reconstitution guidance
- 03Concierge supplier match included with every protocol
See Epitalon pricing — and your supplier match.
Pricing is unlocked once we know who you are. Take the 3-minute quiz and we'll match you to a US or EU dispensary based on your location and protocol fit.
- Live USD price range
- US & EU supplier shortlist
- Concierge sign-off on dosing
Indicative price range: $120–$180 USD