CARDIAC · Injectable
Cardiogen.
Heart-specific cytoprotective peptide
How it works
Class & mechanism.
Class
Cardiac Bioregulator Peptide
Mechanism
Cardiogen (Ala-Glu-Asp-Arg, AEDR) is a synthetic tetrapeptide bioregulator that enters the cell nucleus and binds to DNA-associated proteins, upregulating genes responsible for cardiomyocyte survival, cytoskeletal proteins (actin, vimentin, lamin A/C), and extracellular matrix repair. It suppresses p53 protein expression in cardiac tissue, thereby inhibiting apoptosis in stressed cardiomyocytes and promoting proliferation of cardiac progenitor cells. Simultaneously, it down-regulates pathological fibroblast maturation, reducing scar formation and fibrotic remodeling after ischemic injury.
Did you know
Cardiogen doesn't just repair the heart — it can selectively trigger cancer cell death in tumors while simultaneously protecting cardiac cells from dying, suggesting a mechanism that 'reads' cell health context before deciding whether to save or destroy.
Benefits
What it does.
Reduces cardiomyocyte apoptosis by down-regulating p53 expression in myocardial tissue
Promotes cardiac progenitor cell proliferation and myocardial regeneration after injury
Supports healthy blood pressure through enhanced nitric oxide production and improved endothelial function
Reduces inflammatory markers (CRP, IL-6) and oxidative stress burden in cardiac tissue
Slows age-related cardiac decline by restoring youthful gene expression patterns in heart cells
The science
Peer-reviewed findings.
Research supporting this compound's mechanisms and safety profile.
Cardiogen demonstrated significant stimulating effect on cardiomyocyte proliferation in both young and old rat cardiac tissue; immunohistochemical analysis confirmed decreased p53 expression, indicating inhibition of apoptosis in myocardial tissue
SOURCE · St. Petersburg Institute of Bioregulation and Gerontology; reported in Core Peptides / Atlas of Science review of Khavinson laboratory research
Cardiogen showed dose-dependent inhibition of M-1 sarcoma growth in rat models through development of hemorrhagic necrosis and stimulation of tumor cell apoptosis — suggesting selective pro-survival action in cardiac cells vs. pro-apoptotic action in tumor cells
SOURCE · Levdik & Knyazkin, Russian Academy of Medical Sciences; cited in biotechpeptides.com (2024)
Clinical use over several decades in Russia showed improvements in ischemic heart disease symptoms, heart failure markers, blood pressure (5–15 mmHg systolic reduction), and angina frequency with minimal adverse effects
SOURCE · SeekPeptides review of Russian clinical literature; Revolution Health & Wellness clinical summary (2024)
Protocol
How to use it.
Dosing
Injectable: 5–20 mcg subcutaneously per day, or every other day, as used in research protocols. Oral capsule forms (where available): 20–80 mg/day divided into 1–2 doses with meals. Protocols are typically 10–30 day cycles.
Cycle
Standard cycle: 10–14 days on, repeat 2–4 times per year for maintenance or preventive use. Post-cardiac-event protocols may extend to 20–30 days. Allow 1–3 months between cycles.
Contraindications
When to skip it.
No significant toxicity reported in available research. Use with caution in patients on anticoagulants or anti-hypertensives (additive effects possible). Not FDA-approved; research-grade only. Avoid in pregnancy (insufficient data). Consult physician before combining with cardiac medications.
Always cleared with your concierge before protocol start.
Pricing
What it costs.
Indicative range for Cardiogen, sourced from vetted US and EU dispensing suppliers. Concierge confirms the exact figure once your match is locked.
Indicative range (USD)
Sourced through vetted dispensing partners in the United States and European Union. Concierge confirms the exact figure once your match is locked.
- 0199% purity verified, third-party tested
- 02Includes vial and reconstitution guidance
- 03Concierge supplier match included with every protocol
See Cardiogen pricing — and your supplier match.
Pricing is unlocked once we know who you are. Take the 3-minute quiz and we'll match you to a US or EU dispensary based on your location and protocol fit.
- Live USD price range
- US & EU supplier shortlist
- Concierge sign-off on dosing
Indicative price range: $120–$180 USD