COGNITIVE · Spray
AC-Semax-NH2.
Nootropic peptide for focus and neuroplasticity
How it works
Class & mechanism.
Class
Synthetic Neuropeptide (Acetylated ACTH Analogue)
Mechanism
AC-Semax-NH2 is an N-acetylated, C-terminal amidated derivative of the ACTH(4-7) fragment, engineered for enhanced blood-brain barrier penetration and metabolic stability. Once in the CNS, it rapidly upregulates BDNF and NGF gene expression in the hippocampus and frontal cortex within 20 minutes of administration, driving neuroplasticity and neurotrophic cascades. It also modulates dopaminergic, serotonergic, and noradrenergic neurotransmission, increasing concentrations of these monoamines in key cognitive regions while promoting neuronal survival under hypoxic conditions.
Did you know
Semax was originally developed by the Russian Academy of Sciences in the 1970s and is still prescribed in Russian hospitals today for stroke recovery — it can upregulate the brain's primary growth factor (BDNF) within 20 minutes of a single nasal spray.
Benefits
What it does.
Rapid enhancement of focus, working memory, and mental clarity
Upregulates BDNF and NGF — the brain's own growth factors for plasticity and repair
Neuroprotection: shown to accelerate neurological recovery after stroke and hypoxic injury
Non-stimulant cognitive boost without crash, dependency, or tolerance formation
The science
Peer-reviewed findings.
Research supporting this compound's mechanisms and safety profile.
Single intranasal administration (50 mg/kg in rats) significantly altered BDNF and NGF mRNA levels in both hippocampus and frontal cortex within 20 minutes, with sustained expression changes over several hours.
SOURCE · Europe PMC / Zhurnal Vysshei Nervnoi Deyatelnosti, PMID 18756821
Meta-analysis of Russian clinical trials found Semax (12–18 mg/day intranasal) added to standard care improved neurological deficits faster after acute stroke; 83% of patients in one 69-patient series showed symptom regression mid-first week, with cognitive improvement 4–7 days earlier than controls.
SOURCE · Russian clinical trial meta-analysis (multiple centers)
Semax increases selective attention and memory storage and promotes neuron survival under hypoxia through ACTH(4-7) receptor-mediated signalling and downstream neurotrophic factor induction.
SOURCE · Neuropeptides / European PMC review literature
Protocol
How to use it.
Dosing
200–600 mcg intranasal per session (split across both nostrils); or 100–300 mcg subcutaneous injection. Standard cognitive protocol: once daily in the morning. Clinical neuroprotection doses reach 12–18 mg/day but are medical-only.
Cycle
10–14 day cycles are most common; followed by 7–14 days off. Some protocols use 5 days on / 2 days off. Long-term continuous use not recommended without breaks.
Contraindications
When to skip it.
Avoid in pregnancy or breastfeeding. Use caution with pre-existing psychiatric conditions (anxiety, psychosis) as dopamine/noradrenaline enhancement may be activating. Not recommended in combination with MAOIs or stimulants without supervision.
Always cleared with your concierge before protocol start.
Pricing
What it costs.
Indicative range for AC-Semax-NH2, sourced from vetted US and EU dispensing suppliers. Concierge confirms the exact figure once your match is locked.
Indicative range (USD)
Sourced through vetted dispensing partners in the United States and European Union. Concierge confirms the exact figure once your match is locked.
- 0199% purity verified, third-party tested
- 02Nasal spray, ready to use
- 03Concierge supplier match included with every protocol
See AC-Semax-NH2 pricing — and your supplier match.
Pricing is unlocked once we know who you are. Take the 3-minute quiz and we'll match you to a US or EU dispensary based on your location and protocol fit.
- Live USD price range
- US & EU supplier shortlist
- Concierge sign-off on dosing
Indicative price range: $99–$149 USD